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The appeal of such substitutes is greater due to the perception that they are less harmful than the traditional combusting cigarettes

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Nicotine activates the reward system Its recognized that the addictive properties of smoking are caused by a complex interaction of factorsnot just nicotine

Nicotine stimulates the brain and when its taken out of the equation, fatigue sets in

Figure 3 Feel disgust/fear of the cigarette warning, by warning type Figure 4 Believe smoking cigarettes reduces blood flow to the lower limbs, by warning type Policy implications Our results pose a dilemma for the FDA

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